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|Synonyms||Dnp; 2,4-Dnp; Phenol,2,4-dinitro|
|Molecular Weight||495.735 g·mol−1|
|Usage||to lose weight quickly|
|Grade||Pharmaceutical Grade, Medicine Grade|
|Delivery method||EMS, DHL, TNT, FedEx, HK EMS, EUB
Based on the effects of different additives on ultrasonic degradation of 2,4-dinitrophenol in aqueous solution,2,4-dinitrophenol removal mechanism was primarily proposed. The investigation showed that the sonochemical degradation of 2,4-dinitrophenol was effectively facilitated by CuO,CCl4, O3,KI and NaCl, but markedly inhibited by Na2CO3,which indicates that sonochemical degradation of 2,4-dinitrophenol in aqueous solution was mainly ascribed to the oxidation of hydroxyl radicals.Nitrite concentration generating from 2,4-dinitrophenol decomposition is observed to firstly increase, then decrease as a consequence of the radical oxidation. However, nitrate concentration remained increasing during 2,4-dinitrophenol degradation.
2,4-dinitrophenol (DNP) is a proton ionophore (proton transporter) that acts as a decoupler of oxidative phosphorylation in the mitochondria of the cell.
There namely the utilization of carbohydrates and fatty acids in the so-called respiratory chain, which opens a chemiosmotic potential between the intermembrane space and the mitochondrial matrix and thus u. a. builds up a proton gradient between these two spaces, which is normally used to generate energy in the form of ATP.
In contrast, "decouplers" of oxidative phosphorylation, like DNP, degrade this gradient by taking up protons from the intermembrane space, diffusing them through the inner mitochondrial membrane into the matrix and releasing the protons there again.
In the case of the DNP, this then migrates mesomerically stabilized back into the intermembrane space, where the cycle begins anew, whereas the energy stored in the proton gradient is lost as heat. In order to maintain or rebuild the gradient for operating the ATP synthesis, the cell must consequently increase its metabolism and metabolize, for example, more fatty acids and / or carbohydrates, so that the physiological effect of DNP is ultimately due to nothing else than intensification of the fat. and carbohydrate metabolism.
Of particular physiological importance, the described decoupling of oxidative phosphorylation in the brown adipose tissue of newborns, where it - but there by thermogenin, an endogenous ion channel protein of the inner mitochondrial membrane - also allows a jitter-free heat generation.
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