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CAS 147245-92-9 Healthy Polypeptide Hormones , Glatiramer Acetate C25H45N5O13

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CAS 147245-92-9 Healthy Polypeptide Hormones , Glatiramer Acetate C25H45N5O13

CAS 147245-92-9 Healthy Polypeptide Hormones , Glatiramer Acetate C25H45N5O13
CAS 147245-92-9 Healthy Polypeptide Hormones , Glatiramer Acetate C25H45N5O13 CAS 147245-92-9 Healthy Polypeptide Hormones , Glatiramer Acetate C25H45N5O13 CAS 147245-92-9 Healthy Polypeptide Hormones , Glatiramer Acetate C25H45N5O13 CAS 147245-92-9 Healthy Polypeptide Hormones , Glatiramer Acetate C25H45N5O13

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Product Details:

Place of Origin: China
Brand Name: Holybiological
Certification: ISO9001, SGS
Model Number: CAS NO.: 147245-92-9

Payment & Shipping Terms:

Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: 10mg/vial, 50mg/vial, 100mg/vial or As required
Delivery Time: 24 hours after the payment
Payment Terms: Western Union, MoneyGram, T/T
Supply Ability: 100kg/month
Detailed Product Description
Product Name: Glatiramer Acetate Shipment: FedEx, EMS, HKEMS, TNT, DHL, UPS
Supply: In Stock Policy: Re-Shipping Policy
Appearance: White Powder Contact Us: Holybiological04@holybiological.com
Export Marke: Global Specification: 10mg/vial, 50mg/vial, 100mg/vial
High Light:

steroid peptide hormones

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growth hormone releasing peptide

Healthy Polypeptide Hormones Glatiramer Acetate CAS 147245-92-9

 

Quick details

 

Product name: Glatiramer Acetate
Synonyms: L-Glutamic acid polymer with L-alanine, L-lysine and L-tyrosine, acetate (salt)
CAS No: 147245-92-9
Molecular Weight : 623.65
Molecular Formula : C25H45N5O13
Purity :99% up
Type:  sterile lyophilized powder
Use:  multiple sclerosis
Product Categories: Amino Acids & Derivatives;Intermediates & Fine Chemicals;Peptides;Pharmaceuticals;API

 

Description:

 

Chemically, glatiramer acetate is designated L-glutamic acid polymer with L-alanine, L-lysine and L-tyrosine, acetate (salt).

 

Glatiramer acetate was originally designed to mimic a protein in myelin, called myelin basic protein, with the intention of inducing EAE (an animal model of MS). Quite to the contrary, it was found to suppress the disease and as a result came to be trialed in human MS. There is some evidence that Glatiramer acetate converts the body's immune response from a Th1 type to a Th2 one, promotes suppressor T cells or acts as an altered peptide ligand. Studies in animals and in vitro systems suggest that upon its administration, glatiramer acetate-specific suppressor T-cells are induced and activated in the periphery. Some fraction of the injected material, either intact or partially hydrolyzed, is presumed to enter the lymphatic circulation, enabling it to reach regional lymph nodes, and some may enter the systemic circulation intact.

 

Glatiramer acetate, the active ingredient of COPAXONE, consists of the acetate salts of synthetic polypeptides, containing four naturally occurringamino acids: L-glutamic acid, L-alanine, L-tyrosine, and L-lysine with an average molar fraction of 0.141, 0.427, 0.095, and 0.338, respectively. The average molecular weight of glatiramer acetate is 5,000 – 9,000 daltons. Glatiramer acetate is identified by specific antibodies. 


COPAXONE is a clear, colorless to slightly yellow, sterile, nonpyrogenic solution for subcutaneous injection. Each 1 mL of COPAXONE solution contains 20 mg or 40 mg of glatiramer acetate and the following inactive ingredient: 40 mg of mannitol. The pH of the solutions is approximately 5.5 to 7.0. The biological activity of glatiramer acetate is determined by its ability to block the induction of experimental autoimmune encephalomyelitis (EAE) in mice.

 

CAS 147245-92-9 Healthy Polypeptide Hormones , Glatiramer Acetate C25H45N5O13 0

 

Specification:

 

   Tests

 Specifications

Results

Appearance

A white to slightly yellowish lyophilized materials

Meet the requirement

Solubility

Soluble in water and practically insoluble in acetone

Meet the requirement

Acetate content

(on anhydrous basis)

9.5%-12.0%

10.20%

Average MW (Dalton)

4.7≤MW≤11KDa

7409

 Analysis

(Molar Fraction by HPLC)

L-Alanine: 3.50-5.50

L-Lysine: 2.50-4.50

L-Glutamic acid: 1.20-1.80

L-Tyrosine: 1.00

5.3

4.4

1.7

1.0

Water content(%w/w)

<5%

1.88%

Assay by HPLC(%w/w)

On Anhydrous basis

97.0-105.0%

104.81%

Bacterial endotoxin test

≤6.0EU/mg

Conforms

 

Our Advantages:

 

  1. We have stock so we can delivery quickly at the very day when receive the payment.
  2. Best price, first-class service, high successful delivery rate. A discount would be given when you make a large order.
  3. High quality guarenteed, once any problem is found, the package would be reshipped for you
  4. Shipping by express (FedEx,UPS,DHL,EMS TNT HKEMS), by air.The most professional forwarder would be recommanded for you.
  5. Warm after-sale service for you 24/7. Any of your question would be solved for the first as soon as possible.Adhering to the principle of customer first conviction.we will provide the best and the most sincere services as possible as we can. 

 

CAS 147245-92-9 Healthy Polypeptide Hormones , Glatiramer Acetate C25H45N5O13 1

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