White Powder Human Growth Hormone , Leuprorelin Acetate For Cosmetics

White Powder Polypeptide Hormones Leuprorelin Acetate for Cosmetics

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Product name: Leuprolide Acetate 
CAS No. 74381-53-6
Other Names: Leuprorelin Acetate
MF: C59H84N16O12.C2H4O
Purity: >99%
Grade Standard: Medicine Grade

Description: 

Leuprolide acetate (USAN) is a GnRH analog. Proper Sequence: Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt (Pyr = L-Pyroglutamyl).

Leuprolide acetate injection is a sterile, aqueous solution intended for subcutaneous injection. It is available in a 2.8 mL multiple-dose vial containing 5 mg/mL of Leuprolide acetate, 6.3 mg/mL sodium chloride, USP for tonicity adjustment, 9 mg/mL of benzyl alcohol as a preservative and water for injection, USP. The pH may have been adjusted with sodium hydroxide, NF and/or acetic acid, NF.

Leuprolide acts as an agonist at pituitary GnRH receptors. By interrupting the normal pulsatile stimulation of, and thus desensitizing, the GnRH receptors, it indirectly downregulates the secretion of gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to hypogonadism and thus a dramatic reduction in estradiol and testosterone levels in both sexes.

Clinical use

Leuprolide acetate, an LH-RH agonist, acts as a potent inhibitor of gonadotropin secretion when given continuously and in therapeutic doses. Animal and human studies indicate that following an initial stimulation of gonadotropins, chronic administration of Leuprolide acetate results in suppression of ovarian and testicular steroidogenesis. This effect is reversible upon discontinuation of drug therapy. Administration of Leuprolide acetate has resulted in inhibition of the growth of certain hormone dependent tumors (prostatic tumors in Noble and Dunning male rats and DMBA-induced mammary tumors in female rats) as well as atrophy of the reproductive organs.

In humans, subcutaneous administration of single daily doses of Leuprolide acetate results in an initial increase in circulating levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH), leading to a transient increase in levels of the gonadal steroids (testosterone and dihydrotestosterone in males, and estrone and estradiol in pre-menopausal females). However, continuous daily administration of Leuprolide acetate results in decreased levels of LH and FSH. In males, testosterone is reduced to castrate levels. In pre-menopausal females, estrogens are reduced to post-menopausal levels. These decreases occur within two to four weeks after initiation of treatment, and castrate levels of testosterone in prostatic cancer patients have been demonstrated for periods of up to five years.

An LH-RH (GnRH) analog, leuprolide may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, estrogen-dependent conditions (such as endometriosis oruterine fibroids), to treat precocious puberty, and to control ovarian stimulation in In Vitro Fertilization (IVF). It is considered a possible treatment for paraphilias.
Leuprolide has been tested as a treatment for reducing sexual urges in pedophiles and other cases of paraphilia.

Specification:

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Hubei Holy Biological Co., Ltd. is a professional company, which specialized in developing, manufacturing, distributing steroid hormone powders and intermediates.with advanced production technology and equipment, strong technical force, first-class laboratory and inspection equipment. Holy biological has developed into a professional factory manufacturing anabolic steroid powders with several years' efforts and contribution of experienced technicians in different areas.

Now, holy biological continues its high speed development and contributes a lot to its new products' R&D and quality improvement. Under the credibility and win-win principle, holy biological will devote to culture innovation to provide excellent products and best service to our customers.

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