Product Details:
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Product Name: | Leuprorelin Acetate | Purity: | 99% |
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Shipment: | FedEx, EMS, HKEMS, TNT, DHL, UPS | Supply: | In Stock |
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High Light: | steroid peptide hormones,growth hormone releasing peptide |
White Powder Polypeptide Hormones Leuprorelin Acetate for Cosmetics
Quick details:
Product name: Leuprolide Acetate
CAS No. 74381-53-6
Other Names: Leuprorelin Acetate
MF: C59H84N16O12.C2H4O
Purity: >99%
Grade Standard: Medicine Grade
Description:
Leuprolide acetate (USAN) is a GnRH analog. Proper Sequence: Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt (Pyr = L-Pyroglutamyl).
Leuprolide acetate injection is a sterile, aqueous solution intended for subcutaneous injection. It is available in a 2.8 mL multiple-dose vial containing 5 mg/mL of Leuprolide acetate, 6.3 mg/mL sodium chloride, USP for tonicity adjustment, 9 mg/mL of benzyl alcohol as a preservative and water for injection, USP. The pH may have been adjusted with sodium hydroxide, NF and/or acetic acid, NF.
Leuprolide acts as an agonist at pituitary GnRH receptors. By interrupting the normal pulsatile stimulation of, and thus desensitizing, the GnRH receptors, it indirectly downregulates the secretion of gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to hypogonadism and thus a dramatic reduction in estradiol and testosterone levels in both sexes.
Clinical use
Leuprolide acetate, an LH-RH agonist, acts as a potent inhibitor of gonadotropin secretion when given continuously and in therapeutic doses. Animal and human studies indicate that following an initial stimulation of gonadotropins, chronic administration of Leuprolide acetate results in suppression of ovarian and testicular steroidogenesis. This effect is reversible upon discontinuation of drug therapy. Administration of Leuprolide acetate has resulted in inhibition of the growth of certain hormone dependent tumors (prostatic tumors in Noble and Dunning male rats and DMBA-induced mammary tumors in female rats) as well as atrophy of the reproductive organs.
In humans, subcutaneous administration of single daily doses of Leuprolide acetate results in an initial increase in circulating levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH), leading to a transient increase in levels of the gonadal steroids (testosterone and dihydrotestosterone in males, and estrone and estradiol in pre-menopausal females). However, continuous daily administration of Leuprolide acetate results in decreased levels of LH and FSH. In males, testosterone is reduced to castrate levels. In pre-menopausal females, estrogens are reduced to post-menopausal levels. These decreases occur within two to four weeks after initiation of treatment, and castrate levels of testosterone in prostatic cancer patients have been demonstrated for periods of up to five years.
An LH-RH (GnRH) analog, leuprolide may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, estrogen-dependent conditions (such as endometriosis oruterine fibroids), to treat precocious puberty, and to control ovarian stimulation in In Vitro Fertilization (IVF). It is considered a possible treatment for paraphilias.
Leuprolide has been tested as a treatment for reducing sexual urges in pedophiles and other cases of paraphilia.
Specification:
Leuprorelin Acetate |
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Leuprorelin Acetate CAS 74381-53-6 |
CAS: 74381-53-6 |
Brand: Holybiological |
MW:1269.45 |
MSDS: Avaiable |
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MF :C59H84N16O12.C2H4O2 |
Sample: Avaiable |
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Category: Peptide |
Min order: 1grams |
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Sequence: pGlu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt |
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Usage |
Uses and functions of Leuprorelin Acetate : |
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Applications |
Leuprorelin Acetate Pharmaceutical raw materials |
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