DNA Methyltransferase Inhibitor Active Pharmaceutical Ingredients Decitabine

DNA Methyltransferase Inhibitor Active Pharmaceutical Ingredients Decitabine

Product name: Decitabine
CAS No: 2353-33-5
Molecular Formula: 22FN3O6
Formula Weight: 28.21
Appearance: white or off-white crystalline powder
Assay: 99%

Drug Type:

Decitabine is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. Decitabine is classified as an "antimetabolite" and a "demethylation" agent. For more detail, see "How Decitabine Works" section below.

Used:

Decitabine is used in treatment of myelodysplastic syndrome (MDS).

Note: If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful.

As an infusion into the vein (intravenous or IV).
The actual dosage of Decitabine that you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition you have. Your doctor will determine your exact dosage and schedule.

An article in The New England Journal of Medicine, published January 2007, showed that, compared with placebo, treatment with sorafenib prolongs progression-free survival in patients with advanced clear cell renal cell carcinoma in whom previous therapy has failed. The median progression-free survival was 5.5 months in the sorafenib group and 2.8 months in the placebo group (hazard ratio for disease progression in the sorafenib group, 0.44; 95% confidence interval [CI], 0.35 to 0.55; P<0.01).[11] A few reports described patients with stage IV renal cell carcinomas, metastasized to the brain, that were successfully treated with a multimodal approach including neurosurgical, radiation, and sorafenib.[12] This is one of two TGA-labelled indications for sorafenib, although it is not listed on the British Pharmaceutical Benefits Scheme for this indication.

Specification:

Competitive Advantage:

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